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  • Title: [A study on changes of myosin ATPase activities in cardiac ischemic reperfusion injury of rabbit].
    Author: Zhu B, Wan CM, Guo HL, Xiao J, Wang ZR.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2004 Mar; 35(2):179-81. PubMed ID: 15071909.
    Abstract:
    OBJECTIVE: To investigate the changes of myosin ATPase activities in cardiac ischemic reperfusion injury of rabbit. METHODS: A convenient method was adopted to purify the myosin from the left ventricle of normal rabbit heart and of cardiac ischemic reperfusion injured rabbit heart. The michaelis constant (K(m)) and maximum velocity(Vmax) values of Ca(2+)-activated ATPase were determined from the rate of Pi release in enzymatic reaction. The myosin ATPase activities of normal group and ischemic group were compared. RESULTS: The myosin ATPase activities of the control group were Vmax: (1.15 +/- 0.17) mumol/(mg.min), K(m): (5.43 +/- 2.18) mmol and those of ischemic group were Vmax: (1.17 +/- 0.21) mumol/(mg.min), K(m): (6.02 +/- 2.01) mmol. There was no significant difference between the two groups(P > 0.05). CONCLUSION: This modelling animal experiment showed that the myosin ATPase activities were unchanged in cardiac ischemic reperfusion injury.
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