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  • Title: Comparison of different ibuprofen-amino acid compounds with respect to emulsifying and cytotoxic properties.
    Author: Baydoun L, Düvel A, Daniels R, Drust A, Goldhagen T, Schwan I, Zeidler C, Müller-Goymann CC.
    Journal: Int J Pharm; 2004 Apr 15; 274(1-2):157-65. PubMed ID: 15072792.
    Abstract:
    Sodium ibuprofen (Ibu-Na) and different ibuprofen-amino acid compounds, lysinate (Ibu-Lys), arginate (Ibu-Arg) and histidinate (Ibu-His), were evaluated for emulsifying, haemolytic and cytotoxic properties. The highest reduction of surface tension was obtained with Ibu-Lys which shows good emulsifying qualities. At the same time, Ibu-Lys reveals the highest haemolytic activity and affects porcine cornea integrity. However, incorporation of Ibu-Lys into an emulsion system significantly decreases haemolysis. On the contrary Ibu-Arg, which shows a lower surface tension reduction, allows, unlike Ibu-Na and Ibu-His, for comparably stable emulsions with comparable erythrocyte damage.
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