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  • Title: Inhibitory activity of indolin-2-one derivatives on compound 48/80-induced histamine release from mast cells.
    Author: Rüster GU, Hoffmann B, Hamburger M.
    Journal: Pharmazie; 2004 Mar; 59(3):236-7. PubMed ID: 15074604.
    Abstract:
    Four alkaloids, previously identified in Isatis species, were tested for their inhibitory effect on histamine release. Whereas tryptanthrin, indirubin and deoxyvasicinone did not inhibit histamine release, the effect of indolin-2-one exceeded that of the mast cell stabilizing drug disodium chromoglycate.
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