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  • Title: Molecular monitoring to identify a threshold of CBFbeta/MYH11 transcript below which continuous complete remission of acute myeloid leukemia inv16 is likely.
    Author: Martinelli G, Rondoni M, Buonamici S, Ottaviani E, Piccaluga PP, Malagola M, Baccarani M.
    Journal: Haematologica; 2004 Apr; 89(4):495-7. PubMed ID: 15075086.
    Abstract:
    Many patients with the inv(16) positive acute myeloid leukemia (AML) achieve complete remission (CR). Using real-time reverse transcriptase polymerase chain reaction (RT-PCR), we previously proposed critical CBFbeta-MYH11 transcript copy number thresholds to predict relapse or cure. We now update the molecular follow-up of our patients, also presenting the therapeutic management of these patients.
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