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  • Title: Synthesis and cytotoxic activity of novel quinazolino-beta-carboline-5-one derivatives.
    Author: Baruah B, Dasu K, Vaitilingam B, Mamnoor P, Venkata PP, Rajagopal S, Yeleswarapu KR.
    Journal: Bioorg Med Chem; 2004 May 01; 12(9):1991-4. PubMed ID: 15080902.
    Abstract:
    A novel series of quinazolino-beta-carbolinone derivatives was synthesized and evaluated for their in vitro and in vivo anticancer activity. Many compounds have shown good in vitro activity in the range 1-8 microM concentration. Three of the compounds were further tested in nude mice bearing HT-29 colon cancer xenografts.
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