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  • Title: Prolonged central motor conduction time of lower limb muscle in spinocerebellar ataxia 6.
    Author: Chen JT, Lin YY, Lee YC, Soong BW, Wu ZA, Liao KK.
    Journal: J Clin Neurosci; 2004 May; 11(4):381-3. PubMed ID: 15080952.
    Abstract:
    We investigated the function of corticospinal tract in spinocerebellar ataxia 6 (SCA6) by measuring the central motor conduction time (CMCT). Motor evoked potentials (MEP) of tibialis anterior (TA) muscle were elicited by magnetic stimulation to motor cortex and spinal cord in 9 SCA6 patients and 10 normal height- and age-matched subjects. CMCT in lower limb of SCA6 patients (18.1+/-1.9 ms) was significantly prolonged than that of the normal subjects (15.0+/-1.0 ms) ((p < 0.001). The prolonged CMCT was well correlated with the duration of disease (p = 0.005), but MEP amplitudes and stimulation intensities were not significantly different. These results indicate that the corticospinal tract function is also impaired and correlate with the disease duration in SCA6.
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