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  • Title: Synthesis and biochemical properties of E-ring modified luotonin A derivatives.
    Author: Cagir A, Jones SH, Eisenhauer BM, Gao R, Hecht SM.
    Journal: Bioorg Med Chem Lett; 2004 May 03; 14(9):2051-4. PubMed ID: 15080977.
    Abstract:
    Luotonin A is a cytotoxic pyrroloquinazolinoquinoline alkaloid that has been shown to stabilize the human topoisomerase I-DNA covalent binary complex in the same fashion as the antitumor alkaloid camptothecin. A study of the structural elements in luotonin A required for binary complex stabilization has revealed key differences relative to those required for camptothecin.
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