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  • Title: Thioxanthene-derived analogs as sigma(1) receptor ligands.
    Author: Glennon RA, Ismaiel AM, Ablordeppey S, El-Ashmawy M, Fisher JB.
    Journal: Bioorg Med Chem Lett; 2004 May 03; 14(9):2217-20. PubMed ID: 15081012.
    Abstract:
    An investigation of the structure-affinity relationships for the binding of thioxanthene-related structures indicates that an intact thioxanthene ring is not required for binding at sigma(1) receptors, and that with the appropriate structural modifications, affinity can be enhanced to the subnanomolar level. Certain of the analogs displayed sigma(1)-fold selectivity for sigma(1) versus sigma(2) receptors.
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