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  • Title: Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas.
    Author: Jones S, Lambert S, Williams GT, Best JM, Sampson JR, Cheadle JP.
    Journal: Br J Cancer; 2004 Apr 19; 90(8):1591-3. PubMed ID: 15083190.
    Abstract:
    Colorectal tumours from MYH polyposis patients display an excess of somatic G : C --> T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.005). G : C --> T : A transversions in k-ras were significantly more frequent in MYH polyposis adenomas than in sporadic or familial adenomatous polyposis-associated tumours (P<or=0.002), and all resulted in a glycine-to-cysteine substitution at codon 12.
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