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  • Title: Bayesian estimation of cost-effectiveness from censored data.
    Author: Heitjan DF, Kim CY, Li H.
    Journal: Stat Med; 2004 Apr 30; 23(8):1297-309. PubMed ID: 15083484.
    Abstract:
    We describe a Bayesian methodology for estimating the cost-effectiveness of a new treatment compared to a standard in a clinical trial, when censoring of survival, the effectiveness variable, induces censoring of total cost. The statistical model assumes that survival follows a Weibull distribution and that total health care cost follows a gamma distribution whose mean has a linear regression on survival time. We summarize the posterior distributions of key parameters by importance sampling. We illustrate the method with an analysis of data from a randomized clinical trial of a treatment for cardiovascular disease.
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