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  • Title: Synthesis, biological activity, and quantitative structure-activity relationship study of azanaphthalimide and arylnaphthalimide derivatives.
    Author: Braña MF, Gradillas A, Gómez A, Acero N, Llinares F, Muñoz-Mingarro D, Abradelo C, Rey-Stolle F, Yuste M, Campos J, Gallo MA, Espinosa A.
    Journal: J Med Chem; 2004 Apr 22; 47(9):2236-42. PubMed ID: 15084122.
    Abstract:
    A series of quinoline derivatives as aza analogues of the naphthalene chromophore and a series of "nonfused" tricyclic aromatic systems, in particular 5-arylquinolines and 5- or 6-aryl and heteroaryl naphthalene systems, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. The analysis of quantitative structure-antitumor activity relationships for the growth-inhibitory properties is also reported. Findings suggest that these compounds may not express their cytotoxicity via interaction on DNA.
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