These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Modulatory effect of 8-OH-DPAT on behavior of ovariectomized female rats.
    Author: Sapronov NS, Fedotova YO, Malygina EI.
    Journal: Bull Exp Biol Med; 2004 Jan; 137(1):43-6. PubMed ID: 15085243.
    Abstract:
    Behavior of ovariectomized rats was studied after chronic administration of serotonin 1A receptor agonist 8-OH-DPAT alone or in combination with 17beta-estradiol for 14 days. The effect of 8-OH-DPAT on learning was evaluated in the conditioned passive avoidance task. Behavioral activity in elevated plus-maze and open field was recorded. Administration of 8-OH-DPAT to ovariectomized female rats increased the number of entries into open arms of the maze and the time spent there. Combination treatment of ovariectomized animals with 8-OH-DPAT and 17beta-estradiol decreased total locomotor and emotional activity in the open field. Administration of 8-OH-DPAT alone or in combination with 17beta-estradiol improved performance of the conditioned passive avoidance response.
    [Abstract] [Full Text] [Related] [New Search]