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  • Title: Liver biopsy sampling in chronic viral hepatitis.
    Author: Guido M, Rugge M.
    Journal: Semin Liver Dis; 2004 Feb; 24(1):89-97. PubMed ID: 15085489.
    Abstract:
    In chronic viral hepatitis, liver biopsy is performed to grade and stage liver damage. Liver biopsy samples are usually taken with a needle using a percutaneous procedure. This method produces a core of tissue representing approximately 1/50,000th of the liver mass, which raises concern about how representative a needle biopsy can be. A critical review of the literature reveals methodological limits unacceptable in this era of evidence-based medicine. Integrating earlier experience with more recently produced data indicates that a biopsy sample 2 cm or more in length containing at least 11 complete portal tracts should be reliable for grading and staging chronic viral hepatitis.
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