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  • Title: Distribution of synchronous and metachronous multiple colorectal cancers.
    Author: Ikeda Y, Saku M, Kawanaka H, Muranaka T, Takeshita M, Watanabe J, Yoshida K, Sugimachi K.
    Journal: Hepatogastroenterology; 2004; 51(56):443-6. PubMed ID: 15086178.
    Abstract:
    BACKGROUND/AIMS: Synchronous and metachronous multiple colorectal cancers are not rare occurrences. Since features of colorectal cancer depend on tumor location, we focused attention on the tumor distribution of synchronous and meta-chronous lesions in colorectal cancer. METHODOLOGY: The records of 1812 patients with colorectal malignancies (either invasive colorectal cancer or high grade dysplasia) were clinicopathologically analyzed. RESULTS: In one hundred and twenty patients with colorectal malignancies there were synchronous or metachronous lesions. The distribution of synchronous malignancies showed a significant shift from the proximal to the distal site, while in metachronous malignancies, the distribution of second tumors showed a significant shift from the distal to the proximal site. CONCLUSIONS: Our findings suggest that different types of cancer lesions do exist, hence careful and meticulous examinations are important.
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