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  • Title: [Radiosensitizing effect of a 2-nitroimidazole hydroxamate (KIN-804) to murine tumors].
    Author: Tada T, Nakajima T, Onoyama Y, Nagasawa H, Hori H, Inayama S.
    Journal: Nihon Igaku Hoshasen Gakkai Zasshi; 1992 May 25; 52(5):688-90. PubMed ID: 1508643.
    Abstract:
    We studied the toxicity, pharmacokinesis and radiosensitizing effect of a newly developed 2-nitroimidazole-1-methylacetohydroxamate (KIN-804) in C3H/He mice bearing SCC-VII tumor. They were compared with misonidazole. LD50/7 of KIN-804 and misonidazole were 3200 and 2000 mg/kg. The concentration of KIN-804 in the brain and sciatic nerve was at a very low level and its clearance from the sciatic nerve was rapid. Enhancement ratios calculated using the growth delay method were 1.50 for KIN-804 and 1.36 for misonidazole respectively when they were administered by intraperitoneal injection with a dose of 100 mg/kg. KIN-804 was considered to be a promising radiosensitizer because it obtained less toxicity and a higher radiosensitizing activity than misonidazole.
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