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  • Title: Effect of co-administration of lithium and reboxetine on extracellular monoamine concentrations in rats.
    Author: Kitaichi Y, Inoue T, Nakagawa S, Izumi T, Koyama T.
    Journal: Eur J Pharmacol; 2004 Apr 12; 489(3):187-91. PubMed ID: 15087241.
    Abstract:
    We investigated the effect of reboxetine, a selective noradrenaline reuptake inhibitor, 7 days after treatment with subchronic lithium on extracellular noradrenaline, dopamine and serotonin (5-HT) concentrations in the medial prefrontal cortex. Acute treatment with reboxetine significantly increased extracellular concentrations of noradrenaline and dopamine, but did not alter 5-HT concentrations. Subchronic lithium increased basal levels of extracellular 5-HT, but not noradrenaline or dopamine. Co-administration of reboxetine and lithium treatment increased the extracellular concentrations of noradrenaline, dopamine and 5-HT, though reboxetine alone increased the extracellular levels of noradrenaline and dopamine only. Thus, combined lithium and reboxetine produces an additive effect neurochemically rather than their interaction.
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