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  • Title: [Gln192Arg polymorphism of the paraoxonase-1 gene is not associated with Alzheimer's disease in Chinese].
    Author: Shi JJ, Zhang SZ, Ma C, Tang MN, Liu XH, Wang YC, Han HY, Guo YB, Feng RM, Miao GD.
    Journal: Di Yi Jun Yi Da Xue Xue Bao; 2004 Apr; 24(4):371-4. PubMed ID: 15090300.
    Abstract:
    OBJECTIVE: To explore the relationship between paraoxonase-1 (PON1) gene Gln192Arg polymorphism and sporadic Alzheimer's disease (AD) in Chinese. METHODS: A total of 165 AD patients and 174 age-matched control subjects were enrolled in this study for examination of PON1 Gln192Arg and apolipoprotein E gene polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: The distribution of PON1 allelic and genotypic frequencies did not significantly differ between AD patients and the control subjects, even after the stratification by ApoE-epsilon4 status. CONCLUSION: Gln192Arg polymorphism of the PON1 gene is not associated with sporadic AD in Chinese.
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