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  • Title: Feasibility of breast-conserving therapy for macroscopically multiple ipsilateral breast cancer.
    Author: Okumura S, Mitsumori M, Yamauchi C, Kawamura S, Oya N, Nagata Y, Hiraoka M, Kokubo M, Mise K, Kodama H.
    Journal: Int J Radiat Oncol Biol Phys; 2004 May 01; 59(1):146-51. PubMed ID: 15093910.
    Abstract:
    PURPOSE: Macroscopically multiple ipsilateral breast cancer (MMIBC) is generally considered a contraindication for breast-conserving therapy (BCT). The result of BCT for MMIBC is reported and the feasibility discussed. METHODS AND MATERIALS: Between July 1993 and February 1999, 34 patients with MMIBC underwent BCT at our clinic. The local control, disease-free survival, and cosmetic results in these patients were compared with those of patients with single disease. RESULTS: After wide excision, 21 (62%) of 34 patients with MMIBC had a close surgical margin and the rate was significantly greater than that of patients with a single lesion. However, the size of the boost irradiation field was not significantly increased. At a median follow-up of 98 months, no statistically significant difference was noted in local control, disease-free survival, or cosmetic result compared with patients with a single lesion. CONCLUSION: Although patients with MMIBC frequently had close surgical margins after BCT, it can be a treatment option for these patients as long as the close surgical margin is accurately detected and treated with an appropriate radiation technique.
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