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  • Title: Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis.
    Author: Warren MJ, Roddam LF, Power PM, Terry TD, Jennings MP.
    Journal: FEMS Immunol Med Microbiol; 2004 May 01; 41(1):43-50. PubMed ID: 15094166.
    Abstract:
    Pilin is the major subunit of the essential virulence factor pili and is glycosylated at Ser63. In this study we investigated the gene pglI to determine whether it is involved in the biosynthesis of the pilin-linked glycan of Neisseria meningitidis strain C311#3. A N. meningitidis C311#3pglI mutant resulted in a change of apparent molecular weight in SDS-PAGE and altered binding of antisera, consistent with a role in the biosynthesis of the pilin-linked glycan. These data, in conjunction with homology with well-characterised acyltransferases suggests a specific role for pglI in the biosynthesis of the basal 2,4-diacetamido-2,4,6-trideoxyhexose residue of the pilin-linked glycan.
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