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  • Title: Down-regulation of apoptosis-inducing factor protein by RNA interference inhibits UVA-induced cell death.
    Author: Yuan CQ, Li YN, Zhang XF.
    Journal: Biochem Biophys Res Commun; 2004 May 14; 317(4):1108-13. PubMed ID: 15094383.
    Abstract:
    Apoptosis-inducing factor (AIF) is a caspase-independent apoptosis effector. UVA-induced Raji cell death was not completely inhibited by pan-caspase inhibitor zVAD.fmk. Moreover, AIF translocated from its normal location, the mitochondrial intermembrane space, into the nucleus, and induced peripheral chromatin condensation during the early stage of UVA-inducing cell death. Enforced expression of AIF can induce Raji cell death in a caspase-independent manner. Down-regulation of AIF protein level by RNA interference (RNAi) can reduce UVA-induced Raji cell death, but the combination of down-regulation of AIF and zVAD.fmk almost completely inhibited UVA-induced Raji cell death. All these suggest that caspase and AIF are two independent pathways and that UVA-induced Raji cell death is dependent on caspase and AIF.
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