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  • Title: Deoxypodophyllotoxin reduces skin pigmentation of brown Guinea pigs.
    Author: Choi H, Lee J, Shin HJ, Lee BG, Chang I, Hwang JS.
    Journal: Planta Med; 2004 Apr; 70(4):378-80. PubMed ID: 15095159.
    Abstract:
    In this report, we have demonstrated that deoxypodophyllotoxin from Anthriscus sylvestris (L.) Hoffm decreases UV-induced skin pigmentation of brown guinea pigs. Deoxypodophyllotoxin (0.05 % in propylene glycol: ethanol: water = 5 : 3:2) was topically applied twice daily for two weeks to dorsal skin of brown guinea pigs that were exposed to UV irradiation using a solar simulator. Visual inspection and Fontana-Masson staining both demonstrated that deoxypodophyllotoxin reduced skin pigmentation and total epidermal melanin when compared to that of vehicle-treated areas, suggesting that deoxypodophyllotoxin maybe applicable to treat hyperpigmentation.
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