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  • Title: Nucleoside analogues and mitochondrial toxicity.
    Author: Fleischer R, Boxwell D, Sherman KE.
    Journal: Clin Infect Dis; 2004 Apr 15; 38(8):e79-80. PubMed ID: 15095236.
    Abstract:
    An evaluation of the US Food and Drug Administration's Adverse Event Reporting System identified that patients coinfected with human immunodeficiency virus and chronic hepatitis C virus who were treated with a regimen of ribavirin and didanosine, with or without stavudine, were at increased risk for events associated with mitochondrial toxicity, including fatal hepatic failure, peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lactic acidosis. In response, the US product labels for didanosine and ribavirin have been revised to caution clinicians against coadministration of these drugs.
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