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  • Title: Compound melanocytic nevi with granular cell changes.
    Author: El-Gamal HM, Robinson-Bostom L, Saddler KD, Pan T, Mihm MC.
    Journal: J Am Acad Dermatol; 2004 May; 50(5):765-6. PubMed ID: 15097962.
    Abstract:
    Two cases of compound melanocytic nevi with granular cell changes were studied. Histological examination revealed compound melanocytic nevi with a portion of the dermal component exhibiting a sheet like proliferation of nevoid cells with granular cytoplasm. Immunohistochemically, both populations of cells stained positive for S-100 and Melan-A. However, HMB-45 was positive only for the nevus cells with granular cytoplasm. We believe this represents granular cytoplasmic changes of nevus cells and does not denote malignant transformation.
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