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  • Title: [Synergetic germicidal effect of ultrasonic with glutaraldehyde and its application in clinical disinfection].
    Author: Wang C, Xu X, Yu Q, Liu H.
    Journal: Wei Sheng Yan Jiu; 2004 Jan; 33(1):42-4, 48. PubMed ID: 15098476.
    Abstract:
    OBJECTIVE: To study the synergetic germicidal effect of ulstrasonic with glutaraldehyde and the feasibility of combining ulstrasonic and glutaraldehyde to disinfect endocopes and medical instruments. METHODS: We determined the respective and the synergetic killing rates of Bacillus subtilis var. niger of ulstrasonic and glutaraldehyde using quantitative suspenion germicidal tests and simulated on-the-spot tests. RESULTS: In suspenion germicidal tests, because of the synergetic germicidal effect, the concentration of glutaraldehyde needed for sterilize spores was decreased from 20 mg/ml to 5 mg/ml for the same killing time(4 h), and when the concentrations were still 20 mg/ml, its killing time was shorten from 4 h to 1 h. Further more, the solutions containing 5 mg/ml glutaraldehyde could sterilize spores of Bacillus subtilis var. niger in 2 h. In the simulated on-the-spot tests, the concentration of glutaraldehyde needed for sterilization was decreased from 20 mg/ml to 5 mg/ml and its killing time was shorten from 4 h to 1 h under the synergetic germicidal effect. CONCLUSION: It indicats the feasibility of combining ulstrasonic and glutaraldehyde to disinfect instruments in clinic.
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