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  • Title: Calpains: targets of cataract prevention?
    Author: Biswas S, Harris F, Dennison S, Singh J, Phoenix DA.
    Journal: Trends Mol Med; 2004 Feb; 10(2):78-84. PubMed ID: 15102361.
    Abstract:
    There is emerging evidence to suggest that the unregulated Ca(2+)-mediated proteolysis of essential lens proteins by calpains might be a major contributor to some forms of cataract in both animals and humans. Moreover, recently solved calpain structures have revealed molecular-level details of the activation mechanism used by these proteases, enabling the structure-based design of potent calpain inhibitors with the potential to act as anti-cataract agents. These agents offer the first real hope of an urgently needed alternative to the surgical treatment of at least some forms of cataract and relief from a life-depreciating condition on a global scale.
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