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  • Title: In vitro activity of terbinafine against medically important non-dermatophyte species of filamentous fungi.
    Author: Garcia-Effron G, Gomez-Lopez A, Mellado E, Monzon A, Rodriguez-Tudela JL, Cuenca-Estrella M.
    Journal: J Antimicrob Chemother; 2004 Jun; 53(6):1086-9. PubMed ID: 15102749.
    Abstract:
    OBJECTIVES: The activity in vitro of terbinafine against 442 clinical isolates of several species of filamentous fungi was analysed. METHODS: A broth microdilution test was carried out following the National Committee for Clinical Laboratory Standards reference method, with modifications described previously. RESULTS: The geometric mean (GM) of MICs of terbinafine for non-Aspergillus fumigatus species was 0.24 mg/L whereas the GM for A. fumigatus rose as far as 2.92 mg/L. Terbinafine showed a very strong activity in vitro against Penicillium spp., Paecilomyces spp., Trichoderma spp., Acremonium spp. and Arthrographis spp. with GMs <1 mg/L. However, some species such as Scedosporium spp., Fusarium spp., Scopulariopsis brevicaulis, and most of Mucorales exhibited high MICs of the allylamine with GMs >/= 4 mg/L. CONCLUSIONS: Overall, the GM of MICs of terbinafine was 1.57 mg/L, but significant differences in susceptibilities were seen between genera and species.
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