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  • Title: [Adult T-cell leukemia/lymphoma of bone with multiple pathological fractures].
    Author: Yamamoto Y, Ishii K, Nomura S, Fukuhara S.
    Journal: Rinsho Ketsueki; 2004 Mar; 45(3):247-9. PubMed ID: 15103941.
    Abstract:
    We report a 49-year-old woman who had adult T-cell leukemia/lymphoma (ATL) of the bone with multiple osteolytic lesions and pathological fractures of her extremities. The WBC count was 15,810/microliter with 0-1% of abnormal lymphocytes, but CT scan revealed no lymphadenopathy. Antibodies to HTLV-I were positive, and a right tibial bone biopsy showed infiltration of ATL cells. Monoclonal integration of HTLV-1 proviral DNA was demonstrated in bone tumor cells. Seven weeks later, she died of DIC due to severe infection during extensive chemotherapy.
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