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  • Title: [Temporal bone histopathology exhibiting cochleosaccular degeneration in a patient with profound deafness].
    Author: Saigusa H, Iino Y, Nakamoto Y, Miyazawa T, Murakami Y, Kodera K.
    Journal: Nihon Jibiinkoka Gakkai Kaiho; 2004 Mar; 107(3):195-8. PubMed ID: 15103945.
    Abstract:
    We herein report the histopathological findings of the temporal bone taken from a patient with unilateral profound deafness since early childhood. The patient was a 72-year-old male who died of lung cancer and extensive metastases including the tongue. The patient had a history of profound hearing loss in his left ear since childhood. The histopathological finding of the left temporal bone revealed a severe atrophy of the organ of Corti, a detached and rolled-up tectorial membrane, a moderate loss of the stria vascularis, and a severe loss of spiral ganglion cells. In addition, the macula of the saccule was severely degenerated. The marked degeneration in the inner ear indicated a cochleosaccular disorder, which is a typical temporal bone finding in cases of viral labyrinthitis and hereditary hearing impairment. The present patient was suspected to have suffered cochleosaccular degeneration as a result of an inner ear viral infection during childhood because the number of spiral ganglion cells was significantly reduced because of secondary neural degeneration.
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