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  • Title: New biologically active triterpenoid saponins from Scabiosa tschiliensis.
    Author: Zheng Q, Koike K, Han LK, Okuda H, Nikaido T.
    Journal: J Nat Prod; 2004 Apr; 67(4):604-13. PubMed ID: 15104490.
    Abstract:
    Eleven new triterpenoid saponins, scabiosaponins A-K (1-11), and hookerosides A (12) and B (13) were isolated from the whole plants of Scabiosa tschiliensis. The structures of the new compounds were established on the basis of extensive NMR (DEPT, DQF-COSY, HETCOR, TOCSY, HMQC, HMQC-TOCSY, HMBC, and NOESY) and MS studies coupled with chemical degradations. The biological activity of compounds 1-10, 12, and 13 and prosapogenin 1b were examined against pancreatic lipase. Scabiosaponins E, F, G, I (5, 6, 7, 9), hookerosides A, B (12, 13), and prosapogenin 1b all exhibited strong inhibition of pancreatic lipase in vitro.
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