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  • Title: Isolation of salicin derivatives from Homalium cochinchinensis and their antiviral activities.
    Author: Ishikawa T, Nishigaya K, Takami K, Uchikoshi H, Chen IS, Tsai IL.
    Journal: J Nat Prod; 2004 Apr; 67(4):659-63. PubMed ID: 15104498.
    Abstract:
    The chemical constituents of Homalium cochinchinensis were examined. From the root bark, in addition to the previously reported cochinolide and its beta-glucopyranoside, cochinchiside A (1) and tremulacinol (4) were isolated together with three known compounds [benzoic acid, tremulacin (2), and tremuloidin (3)]. From the leaves, cochinchiside B (5) was isolated as new compound. The structures of the new compounds (1, 4, 5) were determined by spectroscopic and/or chemical methods. Antiviral testing of compounds 2-5 against HSV-1 and HSV-2 showed that tremulacin (2) and cochinchiside B (5) were weakly active. Tremulacin (2) was also weakly active against HIV-1.
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