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  • Title: [Kinetics of liberation of the theophylline in semi-solid matrix based of Gelucire].
    Author: Ortigosa CA, Lasserre YJ.
    Journal: Ann Pharm Fr; 2004 Mar; 62(2):128-32. PubMed ID: 15107730.
    Abstract:
    Dissolution of a tracer included in Gelucire is primarily governed by two physico-chemical nominative parameters of this auxiliary substance which are its melting point and its hydrophily-lypophily balance. As they are not dissociable and their interaction is very significant, the optimisation of a formulation containing a mix of Gelucire cannot be done with polynomial models. An indirect modelisation, as Simplex, is however possible.
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