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  • Title: Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors.
    Author: Lim HS, Park JJ, Ko K, Lee MH, Chung SK.
    Journal: Bioorg Med Chem Lett; 2004 May 17; 14(10):2499-503. PubMed ID: 15109640.
    Abstract:
    Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P(1), syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.
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