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  • Title: Synthesis and biological activity of macrocyclic taxane analogues.
    Author: Tarrant JG, Cook D, Fairchild C, Kadow JF, Long BH, Rose WC, Vyas D.
    Journal: Bioorg Med Chem Lett; 2004 May 17; 14(10):2555-8. PubMed ID: 15109650.
    Abstract:
    A series of paclitaxel analogues possessing a macrocyclic structure between the 7 and 10 positions has been prepared. These compounds possess in vitro activity against a paclitaxel resistant cell line and have in vivo activity comparable to paclitaxel.
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