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  • Title: Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities.
    Author: Jahng Y, Zhao LX, Moon YS, Basnet A, Kim EK, Chang HW, Ju HK, Jeong TC, Lee ES.
    Journal: Bioorg Med Chem Lett; 2004 May 17; 14(10):2559-62. PubMed ID: 15109651.
    Abstract:
    For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C(15) showed the most significant dual COX/5-LOX inhibitory activity.
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