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  • Title: Atomic force microscopy characterization of an electrochemical DNA-biosensor.
    Author: Chiorcea AM, Oliveira Brett AM.
    Journal: Bioelectrochemistry; 2004 Jun; 63(1-2):229-32. PubMed ID: 15110277.
    Abstract:
    Electrode surface characteristics represent an important aspect on the construction of sensitive DNA electrochemical biosensors for rapid detection of DNA interaction and damage. Two different immobilization procedures of double-stranded DNA (dsDNA) at the surface of a HOPG electrode were evaluated by MAC mode AFM performed in air. A thin dsDNA adsorbed film forming a network structure with holes exposing the electrode surface and a thick dsDNA film completely covering the electrode surface, presenting a much rougher structure, were investigated. The DNA surface characteristics and structure are discussed with respect to the degree of surface coverage.
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