These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Voltammetry of osmium-modified DNA at a mercury film electrode: application in detecting DNA hybridization.
    Author: Kostecka P, Havran L, Pivonkova H, Fojta M.
    Journal: Bioelectrochemistry; 2004 Jun; 63(1-2):245-8. PubMed ID: 15110280.
    Abstract:
    Mercury film electrodes (MFE) have recently been used in nucleic acid electrochemical analysis as alternatives to the classical mercury drop ones. DNA modified with osmium tetroxide, 2,2'-bipyridine (Os,bipy) can be detected with a high sensitivity at mercury electrodes via measurements of a catalytic osmium signal. In this paper we show that mercury film on a glassy carbon electrode can be used in voltammetric analysis of Os,bipy-modified DNA. Application of the MFE as a detection electrode in double-surface electrochemical DNA hybridization assay involving osmium labeling of target DNA is demonstrated.
    [Abstract] [Full Text] [Related] [New Search]