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  • Title: Synthesis and biodistribution of (99m)Tc-carbonyltechnetium-labeled fatty acids.
    Author: Chu T, Zhang Y, Liu X, Wang Y, Hu S, Wang X.
    Journal: Appl Radiat Isot; 2004 Jun; 60(6):845-50. PubMed ID: 15110349.
    Abstract:
    In order to image myocardial metabolism, (99m)Tc(CO)(3)(+) complexes containing fatty acids were evaluated. At first, 11-(1-imidazolyl)-undecanoic acid (IUA) and 11-(2-(4-bromo-phenylazo)-1-imidazolyl)-undecanoic acid (BPIUA) were synthesized and the corresponding carbonyltechnetium-labeled complexes were prepared. However, unfortunately similar to those of other technetium-labeled fatty acid analogs, the biodistribution studies of (99m)Tc(CO)(3)-IUA and (99m)Tc(CO)(3)-BPIUA in mice demonstrated poor heart-to-blood ratios, thus these complexes cannot be used as heart-imaging reagents. In addition, Tween-80 can improve the biodistribution of the complexes for myocardial imaging.
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