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  • Title: Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii.
    Author: Kopańska K, Najda A, Zebrowska J, Chomicz L, Piekarczyk J, Myjak P, Bretner M.
    Journal: Bioorg Med Chem; 2004 May 15; 12(10):2617-24. PubMed ID: 15110843.
    Abstract:
    Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5,6-dimethyl-1H-benzotriazole (11) and 5,6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine.
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