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  • Title: Liquid chromatographic method for the determination of rizatriptan in human plasma.
    Author: Chen J, Jiang X, Jiang W, Mei N, Gao X, Zhang Q.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2004 Jun 05; 805(1):169-73. PubMed ID: 15113554.
    Abstract:
    A high-performance liquid chromatographic (HPLC) method with fluorescence detection has been developed for the determination of rizatriptan in human plasma. Following a single-step liquid-liquid extraction with methyl tertiarybutyl ether, the analytes were separated using a mobile phase consisting of 0.05% (v/v) triethylamine in water (adjusting to pH 2.75 with 85% phosphoric acid) and acetonitrile (92:8, v/v). Fluorescence detection was performed at an excitation wavelength of 225nm and an emission wavelength of 360nm. The linearity for rizatriptan was within the concentration range of 0.5-50ng/ml. The intra- and inter-day precisions of the method were not more than 8.0%. The lower limit of quantification (LLOQ) was 0.5ng/ml for rizatriptan. The method was sensitive, simple and repeatable enough to be used in pharmacokinetic studies.
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