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  • Title: [Screening for apoptosis inducers].
    Author: Naito M.
    Journal: Gan To Kagaku Ryoho; 2004 Apr; 31(4):522-5. PubMed ID: 15114694.
    Abstract:
    We carried out a screening for drugs that can induce apoptosis in human monocytic leukemia U937 cells. In the screening, we found that 8-nitrocaffeine induces cell death distinct from typical apoptosis. Morphological and biochemical analysis revealed that reactive oxygen species mediates the 8-nitrocaffeine-induced necrotic cell death.
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