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  • Title: [A case of neck metastasis from hypopharyngeal carcinoma successfully treated with TS-1].
    Author: Kajikawa H, Nario K, Miyahara H.
    Journal: Gan To Kagaku Ryoho; 2004 Apr; 31(4):631-4. PubMed ID: 15114715.
    Abstract:
    We report a case of hypopharyngeal carcinoma with recurrent neck metastasis. Preoperative chemoradiation and pharyngo-laryngo-esophagectomy with bilateral neck dissection was done as first-line therapy. Six months later, the carcinoma metastasized to the right paratracheal lymph node. Because of resistance to chemoradiation (CBDCA) as second-line therapy, we administered TS-1 for the treatment after 60 Gy radiation. The chemotherapy with TS-1 resulted in complete response by diagnostic imaging (CT). There was no sign of recurrence for 1 year after 5 courses of treatment. TS-1, which allows oral chemotherapy on an outpatient basis, would be a useful drug for treatment with radiotherapy in patients with advanced and/or recurrent head and neck cancer.
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