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  • Title: N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists.
    Author: Molteni V, Penzotti J, Wilson DM, Termin AP, Mao L, Crane CM, Hassman F, Wang T, Wong H, Miller KJ, Grossman S, Grootenhuis PD.
    Journal: J Med Chem; 2004 May 06; 47(10):2426-9. PubMed ID: 15115386.
    Abstract:
    Screening of a computationally designed synthetic library led to the discovery of the N-phenylphenylglycines (NPPGs) as a novel class of human corticotropin releasing factor (h-CRF(1)) antagonists. Several NPPGs with greater potency than the original hit 1 were rapidly identified, and resolution of the racemate demonstrated that only the R-enantiomer displays activity. This structural class represents the first example of a non-peptide CRF(1) antagonist with a stereochemically distinct receptor binding affinity.
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