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  • Title: Diacylglycerol's affair with protein kinase C turns 25.
    Author: Newton AC.
    Journal: Trends Pharmacol Sci; 2004 Apr; 25(4):175-7. PubMed ID: 15116719.
    Abstract:
    This year marks the 25-year anniversary of the discovery by Nishizuka and co-workers that diacylglycerol activates the ubiquitous signal transducer protein kinase C. This discovery placed the lipid second messenger-protein kinase C signaling pathway center stage alongside the cAMP-protein kinase A pathway, which was already established as a fundamental mechanism for transducing extracellular signals.
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