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  • Title: Interaction between cytoplasmic (Ca2+--Mg2+) ATPase activator and the erythrocyte membrane.
    Author: Vincenzi FF, Farrance ML.
    Journal: J Supramol Struct; 1977; 7(3-4):301-6. PubMed ID: 151172.
    Abstract:
    Human red blood cells (RBC) contain a cytoplasmic, nonhemoglobin protein which activates the (Ca2+-Mg2+)ATPase of isolated RBC membranes. Results presented in this paper confirm that activation of (Ca2+-Mg2+)ATPase is associated with binding of the cytoplasmic activator to the membrane. Binding of the cytoplasmic activator is reversible and dependent on ionic strength and Ca2+. Cytoplasmic activator is sensitive to trypsin but is not degraded when intact RBC are exposed to trypsin. Cytoplasmic activator does not modify the (Ca2+-Mg2+)-ATPase of membranes from RBC exposed to activator prior to hemolysis. Thus, the activator is located in the cell and appears to act by binding to the inner membrane surface.
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