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  • Title: Limited genetic diversity in polynesians reflected in the highly polymorphic 3'HVR alpha-globin gene marker.
    Author: Hertzberg MS, Mickleson KN, Trent RJ.
    Journal: Hum Hered; 1992; 42(3):157-61. PubMed ID: 1511993.
    Abstract:
    Polynesians from five distinct island groups were studied with DNA probe alpha 3'HVR, a highly polymorphic VNTR (variable number of tandem repeats) minisatellite region associated with the alpha-globin gene cluster. Results showed a paucity of genetic heterozygosity together with clustering of alpha 3'HVR alleles with alpha-globin DNA haplotypes and alpha-globin gene rearrangements. This restricted diversity is consistent with population bottlenecks in the colonization of Polynesia.
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