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  • Title: Antiherpetic mode of action of (22S,23S)-3beta-bromo-5alpha,22,23-trihydroxystigmastan-6-one in vitro.
    Author: Wachsman MB, Castilla V, Talarico LB, Ramirez JA, Galagovsky LR, Coto CE.
    Journal: Int J Antimicrob Agents; 2004 May; 23(5):524-6. PubMed ID: 15120737.
    Abstract:
    The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3beta-bromo-5alpha,22,23-trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Attempts to disclose the mode of action of 6b indicate that a late step of virus multiplication is affected. In the presence of 6b, HSV late protein synthesis was severely diminished and this inhibitory effect of 6b on HSV antigen expression was confirmed by immunofluorescence assays.
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