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  • Title: Polymorphous low-grade adenocarcinoma--a rare and aggressive entity in adolescence.
    Author: Kumar M, Stivaros N, Barrett AW, Thomas GJ, Bounds G, Newman L.
    Journal: Br J Oral Maxillofac Surg; 2004 Jun; 42(3):195-9. PubMed ID: 15121262.
    Abstract:
    Polymorphous low-grade adenocarcinoma (PLGA) is an uncommon tumour that usually affects the minor salivary glands, particularly in the palate. It is rare in young patients, and here we report a case in a teenage girl. She presented at the age of 16, although the lesion had been noticed 2 years previously. The tumour showed histopathological features of PLGA, but recurred locally, behaved aggressively, and ultimately metastasised to cervical lymph nodes. This was accompanied by an altered histological picture, with a papillary cystic pattern and necrosis becoming progressively more prominent. PLGA is not always a low-grade lesion and some tumours, notably those with a papillary cystic growth pattern, may require more aggressive treatment.
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