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  • Title: Management of Eisenmenger syndrome in pregnancy with sildenafil and L-arginine.
    Author: Lacassie HJ, Germain AM, Valdés G, Fernández MS, Allamand F, López H.
    Journal: Obstet Gynecol; 2004 May; 103(5 Pt 2):1118-20. PubMed ID: 15121629.
    Abstract:
    BACKGROUND: Eisenmenger syndrome in pregnancy may be a life-threatening disease despite recent additions to the treatment options. CASE: We present a woman with severe pulmonary hypertension due to Eisenmenger syndrome treated during pregnancy and delivery and postpartum with L-arginine and sildenafil to enhance the nitric oxide pathway. This combination was associated with significant improvement in the mother's clinical and hemodynamic condition and fetal well-being. CONCLUSION: The concomitant use of sildenafil and L-arginine for the management of pulmonary hypertension in pregnancy, combined with multidisciplinary care, permitted a good outcome for the mother and her infant.
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