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  • Title: [Early isosexual precocious pseudopuberty revealing a juvenile granulosa cell tumor in a six-year-old girl].
    Author: Kdous M, Hachicha R, Gamoudi A.
    Journal: Gynecol Obstet Fertil; 2004 Apr; 32(4):311-4. PubMed ID: 15123101.
    Abstract:
    Juvenile granulosa cell tumors of the ovary are a rare form of neoplasm that makes up less than 5% of ovarian tumors in childhood and adolescence. About 90% are diagnosed in stage I (FIGO) with a favorable prognosis, whereas those at higher stages have a less favorable outcome. The authors describe a juvenile granulosa cell tumor expressed by an early pseudopuberty occurring in a 6-year old child. Clinically, an endocrine syndrome was associated with a pelvic mass. Hyperoestrogenia and serum alphafoetoprotein level were biologically detected. Tumor was localized strictly to the ovary, so conservative surgery was applied and proved sufficient to remove all tumor tissue. Histological examination showed typical microscopic aspect of a juvenile granulosa cell tumor. The patient is well 14 years after surgery with normal growth and mental development.
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