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  • Title: Cytotoxic alkaloids from the roots of Tylophora atrofolliculata.
    Author: Huang X, Gao S, Fan L, Yu S, Liang X.
    Journal: Planta Med; 2004 May; 70(5):441-5. PubMed ID: 15124090.
    Abstract:
    Four new phenanthroindolizidine alkaloids, tylophoridicines C-F, together with three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence. These alkaloids exhibited cytotoxic activity in vitro on HCT-8 cell (with IC50 values in the range 0.083 to 18.99 microM) and KB cell (in the range 3.56 to 18.22 microM) lines.
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